Lady Gaga is the cover star of the latest issue of VOGUE. Photographed by her long-time collaborators Inez & Vinoodh, the actress opens up about her new movie A Star Is Born, her upcoming Las Vegas show Enigma, and celebrating a decade in showbiz. 

Click here to read the cover story, or enjoy excerpts from the interview below...

On working with Bradley Cooper:
He sings from his gut, from the nectar! I knew instantly: This guy could play a rock star. And I don't think there are a lot of people in Hollywood who can. That was the moment I knew this film could be something truly special.

On her first Las Vegas residency:
I've always hated the stigma around Las Vegas—that it’s where you go when you're on the last leg of your career. Being a Las Vegas girl is an absolute dream for me. It's really what I've always wanted to do. We're plowing away, making something brand-new, but still with the iconography that we've already created—and making sure fans leave with the feeling that they went home for a bit with their community.

On dealing with fibromyalgia:
I get so irritated with people who don’t believe fibromyalgia is real. For me, and I think for many others, it's really a cyclone of anxiety, depression, PTSD, trauma, and panic disorder, all of which sends the nervous system into overdrive, and then you have nerve pain as a result. People need to be more compassionate. Chronic pain is no joke. And it's every day waking up not knowing how you're going to feel.

The October issue of VOGUE is available on newsstands nationwide on September 25th.