DNA Study Reveals Where You Live May Change How Fast You Age

[RAMROD 117,127]

University of Manchester scientists, part of a global team led by Stanford University, have uncovered a remarkable link between where you live and how quickly your body ages.

Publishing in one of the world’s leading scientific journals Cell, the researchers analysed 322 healthy people from Europe, East Asia and South Asia to build the most detailed picture yet of how genetic ancestry and environment shape our biology.

They used a sweeping “multiomics” approach, measuring everything from genes and proteins to gut bacteria, metabolic chemicals and metals to understand how ethnicity and geography shape our biology.

By recruiting people of the same genetic ancestry living on different continents, the scientists were able to separate the effects of DNA from the influence of environment with unprecedented clarity.

Genetic ancestry refers  to the estimation of where your ancestors came from based on patterns in your DNA, inherited across generations.

They found that your ethnic background leaves a deep mark on your immune system, metabolism and gut bacteria no matter where you move.

South Asian volunteers showed signs of higher exposure to pathogens across multiple biological layers.

European participants had richer gut microbial diversity and higher levels of chemicals tied to heart disease risk.

But geography also rewired key molecular networks involved in cholesterol, inflammation and energy processing.

Moving continents was enough to shift major metabolic pathways and alter the balance of gut microbes.

The most dramatic finding was that geography appears to change biological age — the molecular measure of how old your cells look.

East Asians living outside Asia were biologically older than those who stayed in Asia.

Europeans showed the opposite pattern, appearing biologically younger when living outside Europe.

The researchers say this suggests environment and genetic ancestry interact in surprising ways that could speed up or slow down ageing.

The study also uncovered a never-before-seen link between a telomerase gene involved in cellular ageing and a specific gut microbe, connected through a lipid molecule called sphingomyelin.

This unexpected three-way link hints at a molecular chain reaction through which gut bacteria may influence how quickly our cells age.

The findings create a powerful new resource for precision medicine, highlighting the need for healthcare tailored to genetic ancestry and environment rather than a one-size-fits-all model.

The researchers say their open-access dataset will help scientists and clinicians develop more accurate diagnostics, treatments and prevention strategies tailored to genetic ancestry, environment and individual biology.

https://www.manchester.ac.uk/about/news/world-first-dna-study-where-you-live-may-change-how-fast-you-age/

[Murakami27 8,479]

Hold on. Let me move to Asia so I can stay younger 

[Economy 52,861]

So basically my ass that was on antibiotics non stop as a kid and then strong ones as a teenager for 2 years straight to fight acne and now has dysfunctional gut is screwed

 

Ive tried for years to eat fibres and prebiotics and i cant seem to recover. Pretty sure i have entire strains of bacteria that are now completely extinct and no amount of healthy eating will fix it