Luiz 4,253 Posted May 1, 2015 Share Posted May 1, 2015 What do you do when a patient needs a blood transfusion but you don’t have their blood type in the blood bank? It’s a problem that scientists have been trying to solve for years but haven’t been able to find an economic solution – until now.University of British Columbia chemists and scientists in the Centre for Blood Research have created an enzyme that could potentially solve this problem. The enzyme works by snipping off the sugars, also known as antigens, found in Type A and Type B blood, making it more like Type O. Type O blood is known as the universal donor and can be given to patients of all blood types.“We produced a mutant enzyme that is very efficient at cutting off the sugars in A and B blood, and is much more proficient at removing the subtypes of the A-antigen that the parent enzyme struggles with,” said David Kwan, the lead author of the study and a postdoctoral fellow in the Department of Chemistry.To create this high-powered enzyme capable of snipping off sugars, researchers used a new technology called directed evolution that involves inserting mutations into the gene that codes for the enzyme, and selecting mutants that are more effective at cutting the antigens. In just five generations, the enzyme became 170 times more effective.With this enzyme, UBC associate professor Jayachandran Kizhakkedathu and colleagues in the Centre for Blood Research were able to remove the wide majority of the antigens in Type A and B blood. But before it can be used in clinical settings, the enzyme used would need to remove all of the antigens. The immune system is highly sensitive to blood groups and even small amounts of residual antigens could trigger an immune response.“The concept is not new but until now we needed so much of the enzyme to make it work that it was impractical,” says Steve Withers, a professor in the Department of Chemistry. “Now I’m confident that we can take this a whole lot further.”The study was published in the Journal of the American Chemical Society and was supported by the Canadian Institutes of Health Research and Canadian Blood Services. http://science.ubc.ca/news/researchers-closer-being-able-change-blood-types I disapprove of what you say, but will defend to the death your right to say it. Link to post Share on other sites More sharing options...
Alii 2,039 Posted May 1, 2015 Share Posted May 1, 2015 That's brilliant. Link to post Share on other sites More sharing options...
Guest Posted May 1, 2015 Share Posted May 1, 2015 Oh my, this is amazing news!!! Link to post Share on other sites More sharing options...
Mariann 301 Posted May 1, 2015 Share Posted May 1, 2015 I was just about to ask why would somebody want to change their blood type but this sounds indeed useful. I hope it works. Link to post Share on other sites More sharing options...
Ribs 160 Posted May 1, 2015 Share Posted May 1, 2015 Wow, this is great. Amazing what science can do nowadays. I hope I can contribute similar things once I become a professional Link to post Share on other sites More sharing options...
Dangerous Man 9,245 Posted May 1, 2015 Share Posted May 1, 2015 So we are close in changing humans into mutants? I want to be ice man if that happens. Because he's cool. "A little less conversation and a little more touch my body." Link to post Share on other sites More sharing options...
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